Many native plants have been used in traditional medicine to treat cutaneous leishmaniasis, and recent clinical trials have proven the effectiveness of some of them. Research on these plants has shown that garlic, oysters, wood worm, yarrow, walnut, thyme, henna, mimosa, aloe, black bean, etc. are effective on cutaneous leishmaniasis. Artificial agents in the Iranian market have disadvantages such as high costs and side effects and are painful. Due to the effectiveness of these herbs in injections, they can be a source of natural and safe compounds for the treatment of Leishmania. Therefore, more clinical research should be done to determine the effectiveness and safety of these herbs, their active ingredients and potential toxins that lead to the production of effective and safe drugs for leishmaniasis. It may also be an effective herbal ointment for wound healing.