Cardiovascular disease is one of the leading causes of morbidity and mortality in the world. One of the most important risk factors for cardiovascular disease is hyperlipidemia, especially its high levels. Serum Cholesterol Due to the importance of low blood cholesterol, as a serious disease, various treatments are used to control it, regardless of the cause, most treatments focus on reducing serum lipid levels. This study was conducted to determine different perspectives on blood cholesterol in traditional Iranian medicine. We used the sources and literature of traditional Iranian medicine. Based on these texts, a pilot study was designed to evaluate their effects in 10 patients with high plasma cholesterol. Signs and symptoms in the main digestive organs (stomach and liver) were also examined. Some patients had a hepatic temperament but all patients had a gastric temperament.